ECHA is seeking comments on harmonised classification and labelling (CLH) proposals for two borates and the pesticide fenpyroximate. The public consultations will be open for 45 days and will end on 14 June 2013.

As part of an effort to identify RELs that may not be adequate to protect workers from adverse health effects due to exposure, NIOSH is reexamining the existing REL for diethanolamine. The agency is requesting information, including published and unpublished reports and research findings, to evaluate the health risks associated with occupational exposure to diethanolamine. Comments and materials must be received by June 24, 2013.

Effective April 19, 2013, the Office of Environmental Health Hazard Assessment (OEHHA) is removing bisphenol A (BPA) (CAS No. 80-05-7) from the list of chemicals known to the State to cause cancer or reproductive toxicity. This action comes as a result of a preliminary injunction requiring OEHHA to delist the chemical pending final resolution of the case between the American Chemistry Council and the Office of Environmental Health Hazard Assessment, et al.

In March of 2012, the Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice of Proposed Rulemaking proposing Maximum Allowable Dose Levels (MADLs) for the chemical methanol. After a public comment period and hearings, on April 10, 2013 the Office of Administrative Law (OAL) approved the proposal which will become effective July 1, 2013.

Effective April 11, 2013, the Office of Environmental Health Hazard Assessment (OEHHA) is adding bisphenol A (BPA) (CAS No. 80-05-7) to the list of chemicals known to the State to cause reproductive toxicity for purposes of Proposition 65.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list Clomiphene Citrate (CAS 911-45-5) as known to the State to cause cancer under Proposition 65. This action is being proposed under the “formally required to be labeled or identified” listing mechanism.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical hydrogen cyanide and cyanide salts as known to the State to cause reproductive toxicity (male reproductive toxicity endpoint) under Proposition 65. This action is being proposed under the authoritative bodies listing mechanism.

The first annual update of the Community rolling action plan (CoRAP) for 2013-2015 is now available. It contains 115 substances of which 62 are newly allocated and 53 come from the first CoRAP adopted in 2012. The Member States will evaluate those substances under the substance evaluation process of the REACH Regulation in 2013, 2014, and 2015.

ECHA is launching a public consultation on SEAC's draft opinion on a restriction proposal for 1,4-dichlorobenzene in air fresheners and toilet blocks. The deadline for comments is 17 May 2013. Comments will be reviewed and considered by SEAC in its final opinion, which is scheduled for adoption by 19 June 2013.

The Office of Environmental Health Hazard Assessment (OEHHA) is revising the Maximum Allowable Dose Level (MADL) for sulfur dioxide proposed for adoption into regulation (Title 27, California Code of Regulations, section 25805). The MADL was first proposed as 220 micrograms per day on July 6, 2012. The new proposed MADL is 10,000 micrograms per day.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether Trichloroethylene (TCE), Methyl Isobutyl Ketone, and Emissions from Combustion of Coal meet the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as Proposition 65. This action is being proposed under the authoritative bodies listing mechanism.

The joint study calls for more research to understand fully the associations between endocrine disrupting chemicals (EDCs) - found in many household and industrial products - and specific diseases and disorders.

Effective February 8, 2013, the Office of Environmental Health Hazard Assessment (OEHHA) is adding C.I. Disperse Yellow 3 (CAS No. 2832-40-8) and 2,6-dimethyl-N-nitrosomorpholine (DMNM) (CAS No. 1456-28-6) to the list of chemicals known to the State to cause cancer.

ECHA is looking for comments on two harmonised classification and labelling (CLH) proposals, for sulfoxaflor and 1,2-epoxybutane. The public consultations will be open for 45 days and will end on 25 March 2013.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemical Bisphenol A as known to the State to cause reproductive toxicity (developmental endpoint) under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism. OEHHA is requesting comments as to whether Bisphenol A meets the criteria for authoritative bodies listing.

The meeting, scheduled for March 21, 2013, is open to the public with time set aside for oral public comment. The NTP also invites written and oral public comments on the draft monographs. The deadline for submission of written comments is March 7, 2013,

Originally scheduled for November 29-30, 2012, this meeting has now been rescheduled for January 8-9, 2013. This workshop is designed to discuss the planning for EPA’s toxicological review of chronic exposure to inorganic arsenic (iAs) (cancer and non-cancer effects), which EPA intends to post to the IRIS database.

The List of the EDSP Universe of Chemicals contains approximately 10,000 chemicals as defined under FFDCA and SDWA 1996 amendments, although not all of the chemicals are expected to undergo EDSP Tier 1 screening. The agency plans to prioritize these chemicals for screening by considering physical chemical properties, exposure, and an effect-based approach using advanced computational toxicological methods.

The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) has selected Butyl Benzyl Phthalate to review for possible listing under Proposition 65 and is initiating the development of hazard identification materials on this chemical. By this notice, OEHHA is giving the public an opportunity to provide information relevant to the assessment of the evidence of carcinogenicity for this chemical. In order to be considered, the relevant information must be received at OEHHA by 5:00 p.m. on Tuesday, January 22, 2013.

ECHA is giving the parties concerned an opportunity to comment on questions related to the potential reproductive toxicity of cycloxydim (EC No 405-230-9, CAS No 101205-02-1) which is currently under discussion by the Committee for Risk Assessment (RAC).

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding α-methyl styrene (alpha-methylstyrene) (CAS No. 98-83-9) and 1,3-dinitropyrene (CAS No. 75321-20-9) to the list of chemicals known to the State of California to cause cancer. The listing of these two chemicals is effective November 2, 2012.

ECHA is seeking comments on new proposals for harmonised classification and labelling (CLH) for lead and for three active substances in plant protection products: carvone, metaldehyde and dimethenamid-P.

Earlier this year the Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice of Proposed Rulemaking proposing a No Significant Risk Level (NSRL) for the chemical tris (1,3-dichloro-2-propyl) phosphate (TDCPP). On September 20, 2012, following the public comment period, the Office of Administrative Law (OAL) approved the adoption of the NSRL for tris (1,3-dichloro-2-propyl) phosphate and the amendment to Title 27, California Code of Regulations, section 25705(b).

The Committee for Risk Assessment (RAC) has adopted opinions on harmonised classification and labelling across Europe for the following 5 substances: Cymoxanil; 4-vinylcyclohexene (VCH); Fenoxycarb; Tralkoxydim; Penconazole.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list Alpha-methylstyrene and 1,3-Dinitropyrene as known to the State to cause cancer under Proposition 65. OEHHA is providing the opportunity to comment as to whether the chemicals identified above meet the requirements for listing as causing cancer. Comments must be received by 5:00 p.m. on Monday, October 15, 2012.

The public consultation will be open for 45 days and will end on 18 October 2012. Interested parties can post their comments on the ECHA website.

The EPA is seeking public comments on the draft report titled "An Alternatives Assessment for the Flame Retardant Decabromodiphenyl Ether (DecaBDE)". Comments must be received by September 30, 2012.

Effective July 24, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding two chemicals, isopyrazam (CAS No. 881685-58-1) and 3,3’,4,4’-tetrachloroazobenzene (CAS No. 14047-09-7), to the list of chemicals known to the State to cause cancer.

The EPA has posted the Endocrine Disruptor Screening Program (EDSP) Comprehensive Management Plan on its website. The EDSP Comprehensive Management Plan provides strategic guidance for agency personnel and outlines the critical activities that are planned for this program over the next five years. The plan is intended as an internal planning document, but is being made available to the public in order to be as transparent as possible.

IRIS announces the availability of the literature search for acrylonitrile (107-13-1) and is asking the public for any additional scientific information on health effects that may result from exposure to this chemical substance.

EPA has announced the release of the draft IRIS Toxicological Review of Trimethylbenzenes (External Review Draft) for a 60-day public review and comment period. An upcoming Federal Register Notice will announce a public listening session to be held on August 1, 2012, and the close of the comment period as August 28, 2012. [Federal Register Notice Jun 29, 2012]

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding benzophenone (CAS No. 119-61-9), coconut oil diethanolamine condensate (cocamide diethanolamine) (CAS No. 68603-42-9), diethanolamine (CAS No. 111-42-2), and 2-methylimidazole (CAS No. 693-98-1) to the list of chemicals known to the State of California to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of these four chemicals is effective June 22, 2012.

After a week-long meeting of international experts, the International Agency for Research on Cancer (IARC), which is part of the World Health Organization (WHO), today classified diesel engine exhaust as carcinogenic to humans (Group 1), based on sufficient evidence that exposure is associated with an increased risk for lung cancer.

EPA is announcing the release of the IRIS Progress Report to Congress. This report, delivered to Congress on April 20, 2012, provides Congress, stakeholders, and the public with an update on the IRIS Program and EPA’s progress toward implementing the recommendations from the National Research Council (NRC), received in April 2011, for improving the development of IRIS assessments.

EPA is announcing the release of the draft IRIS Toxicological Review of Ammonia (External Review Draft) for public review and comment. The 60-day public review and comment period will begin with publication of a Federal Register Notice (anticipated June 8, 2012). The Federal Register Notice will also announce a public listening session to be held on July 12, 2012.

The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals isopyrazam and 3,3',4,4' tetrachloroazobenzene as known to the State to cause cancer. OEHHA is providing the opportunity to comment as to whether the chemicals identified above meet the requirements for listing. Comments must be received by Monday, June 25, 2012.

ECHA invites the parties concerned to comment on five new proposals for harmonised classification and labelling (CLH): Isoxaflutole, Tembotrione, Metosulam, Potassium sorbate and Tetrakis(2,6-dimethylphenyl)-m-phenylene biphosphate. The public consultation will be open for 45 days and will end on 28 June 2012. The CLH reports and the dedicated webform to post the comments are available on the ECHA website.

EPA has developed a new schedule for completing the IRIS Acrylonitrile assessment. The Agency has decided to make further revisions to the acrylonitrile assessment to more fully address scientific issues in the assessment. The revised draft acrylonitrile assessment will be released for public comment and rigorous, independent expert peer review. EPA will seek to have the peer review performed by the new Chemical Assessment Advisory Committee that is being formed under the auspices of the Science Advisory Board.

EPA is announcing the IRIS 2012 agenda and requesting scientific information on health effects that may result from exposure to the chemical substances on the agenda, including assessments that EPA is starting this year.

Public comments on the possible listing of Benzophenone, Coconut Oil Diethanolamine Condensate (Cocamide Diethanolamine), Diethanolamine, and 2-Methylimidazole are now available.

Effective March 16, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding methanol (CAS No. 67-56-1) to the list of chemicals known to the State to cause reproductive toxicity for purposes of Proposition 65.

The Committee for Risk Assessment (RAC) has adopted opinions on proposals for the harmonised classification and labelling for the following chemicals: Proquinazid, Amidosulfuron, Tebufenpyrad, and 1,1',1''-nitrilotripropan-2-ol (TIPA).

EPA has developed a new schedule for completing the IRIS hexavalent chromium assessment. Based on the recommendations of the external peer review panel, which met in May 2011 to review the draft IRIS assessment for hexavalent chromium (oral exposure only), EPA will consider the results of recently and soon to be completed peer-reviewed primary research on the chemical before finalizing the IRIS assessment. The oral assessment will be revised to address the peer review comments and combined with the inhalation assessment, which is currently in draft development. EPA anticipates that the draft assessment for hexavalent chromium (oral and inhalation) will be released for public comment and external peer review in 2013.

ECHA has published new proposals to identify an additional thirteen chemicals as Substances of Very High Concern (SVHCs). Interested parties are invited to join the public consultation by posting their comments on the ECHA website. The public consultation will be open for 45 days and will end on 12 April 2012.

On January 20, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) published a Notice of Intent to List Benzophenone, Coconut oil diethanoamine condensate (cocamide diethanolamine), Diethanolamine), and 2-Methylimidazole as known to the State to cause cancer. OEHHA received a request seeking an extension of the comment period and subsequently extended the comment period until 5 p.m., Thursday, March 22, 2012.

Effective February 17, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding methyl isopropyl ketone (CAS No. 563-80-4) to the Prop 65 list of chemicals known to the State to cause reproductive toxicity.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether the chemicals isopyrazam, beta-myrcene, pulegone, and 3,3',4,4'-tetrachloroazobenzene meet the criteria for listing as known to the State to cause cancer under Prop 65.

Effective February 3, 2012, the Office of Environmental Health Hazard Assessment (OEHHA) is adding kresoxim-methyl (CAS No. 143390-89-0) to the list of chemicals known to the State to cause cancer.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list Benzophenone, Coconut oil diethanolamine condensate (cocamide diethanolamine), Diethanolamine, and 2-Methylimidazole as known to the State to cause cancer under Proposition 65. OEHHA is providing the opportunity to comment as to whether the chemicals identified above meet the requirements for listing as causing cancer. Comments must be received February 21, 2012.

The Developmental and Reproductive Toxicant Identification Committee (DARTIC) of OEHHA’s Science Advisory Board has selected Deltamethrin and Xylene for possible listing under Proposition 65. OEHHA is seeking public comments and information relevant to the assessment of the evidence of developmental and male and female reproductive toxicity. The comment period ends March 20, 2012.

The NTP has published a Federal Register notice seeking comments on several substances, mixtures, and exposure circumstances (collectively referred to as ‘‘substances’’) nominated for possible review for future editions of the Report on Carcinogens (RoC).The Agency is also seeking additional nominations for consideration.

The Office of Environmental Health Hazard Assessment (OEHHA) is providing notice of a change to a proposed regulation establishing a No Significant Risk Level (NSRL) for chlorothalonil. The proposed NSRL published on March 18, 2011, for chlorothalonil has been changed to 41 micrograms per day. A copy of the text of the amended proposed regulation is available on the OEHHA website.

Today's Federal Register announces the availability of the the final process for the preparation of The Report on Carcinogens (Roc). A document describing the new RoC process is now available on the NTP website.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list methyl isopropyl ketone as known to the State to cause reproductive toxicity under Proposition 65. OEHHA is providing the opportunity to comment as to whether the chemical identified above meets the requirements for listing as causing reproductive toxicity. Comments must be received by 5:00 p.m. on Monday, January 30, 2012.

The European Chemicals Agency has submitted to the European Commission a recommendation that thirteen Substances of Very High Concern should in future not be used without authorisation. These substances are all classified because of their carcinogenic, mutagenic or toxic to reproduction (or a combination thereof) properties. They are used in applications where there is potential for worker exposure.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals kresoxim-methyl and tetraconazole as known to the State to cause cancer.OEHHA is requesting comments as to whether these chemicals meet the criteria set forth in the Proposition 65 regulations. Comments must be received by 5:00 p.m. on Tuesday, January 17, 2012.

The U.S. Environmental Protection Agency (EPA) invites public nominations of scientific experts to be considered for appointment to the EPA's Science Advisory Board (SAB) Chemical Assessment Advisory Committee to provide advice through the chartered SAB regarding Toxicological Reviews of environmental chemicals available on EPA's Integrated Risk Information System (IRIS).

The Office of Environmental Health Hazard Assessment (OEHHA) has changed the listing of “Glasswool fibers (airborne particles of respirable size)” to read "Glass wool fibers (inhalable and biopersistent)". This change is based on the identification used in the 12th Report on Carcinogens.

EPA announced the release of the Toxicological Review of Vanadium Pentoxide in a September 30, 2011 Federal Register Notice. This draft assessment was provided for public viewing and comment. The deadline for comments has been extended until December 29, 2011 as announced in a November 9, 2011 Federal Register Notice. The originally scheduled public listening session has also been re-scheduled to December 8, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) has selected C.I. Disperse Yellow 3 and Dibenzanthracenes and dibenz[a,c]anthracene for review for possible listing under Proposition 65. OEHHA is initiating the development of hazard identification materials on these chemicals.

WHO invites public and peer review comment on the Concise International Chemical Assessment Document (CICAD) for Chromium(VI), also known as hexavalent chromium. Following this public comment period, submissions will be reviewed and the document will be finalized by the CICAD Final Review Board.

The Office of Environmental Health Hazard Assessment (OEHHA) is adding five chemicals – estrogen-progestogen (combined) used as menopausal therapy, etoposide (CAS No. 33419-42-0), etoposide in combination with cisplatin and bleomycin, methyl isobutyl ketone (CAS No. 108-10-1) and MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) (CAS No. 113803-47-7) -- to the list of chemicals known to the state to cause cancer. The listing of these five chemicals is effective November 4, 2011.

The NTP is proposing changes to the review process for listing in the Report on Carcinogens and is convening a listening session on November 29, 2011 to receive oral comments

Effective October 28, 2011, the Office of Environmental Health Hazard Assessment (OEHHA) is adding tris(1,3-dichloro-2-propyl) phosphate (TDCPP) (CAS No. 13674-87-8) to the list of chemicals known to the State to cause cancer.

EPA has announced the IRIS Toxicological Review of Biphenyl (External Review Draft) in a September 30, 2011 Federal Register Notice, for public review and comment. This FRN also announces a public listening session to be held on November 16, 2011. The deadline for comments is November 29, 2011.

EPA announces the release of the Toxicological Review of Vanadium Pentoxide in a September 30, 2011 Federal Register Notice. This draft assessment is provided for public viewing and comment. This FRN is also announcing a public listening session that will be held on November 17, 2011. The deadline for comments is November 29, 2011.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list Estrogen–progestogen (combined) used as menopausal therapy, Etoposide, Etoposide in combination with cisplatin and bleomycin, Methyl isobutyl ketone, and MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) as known to the State to cause cancer. OEHHA will accept public comments until October 17th, 2011.

The NTP is postponing the release of the Draft NTP Monograph on Potential Developmental Effects of Cancer Chemotherapy during Pregnancy and the peer review panel meeting. Release of the draft monograph was scheduled for September 9, 2011, and the meeting for October 19-20, 2011; both were announced on August 17, 2011 (76 FR 51034). Information about rescheduling the release of the draft monograph and the peer review will be announced in the Federal Register and posted on the NTP Web site.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding titanium dioxide (airborne, unbound particles of respirable size) to the list of chemicals known to the State of California to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing does not cover titanium dioxide when it remains bound within a product matrix. The listing of titanium dioxide (airborne, unbound particles of respirable size) is effective September 2, 2011.

Hexavalent chromium (CrVI) has been a chemical under consideration for ESL development since 2006. The Toxicology Division is now in the initial stages of starting the Development Support Document (DSD) process for CrVI and is accepting toxicity information from interested parties who would like to submit relevant data. The TCEQ is aware of the recent California EPA and draft USEPA oral assessments of CrVI and the current ongoing research on the mode of action for CrVI. While DSDs have historically only developed inhalation toxicity factors, the DSD for CrVI may also include oral toxicity factors. The deadline for submitting information (e.g., relevant studies, data) is November 15, 2011.bmit relevant data.

This Monograph will be peer reviewed by an NTP Peer Review Panel at a meeting on October 19–20, 2011. The meeting is open to the public with time scheduled for oral public comment. The NTP also invites written comments which should be received by October 5, 2011.

The National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) will hold a public meeting to discuss and obtain comments on the draft document, "Criteria for a Recommended Standard: Occupational Exposure to Diacetyl and 2,3-pentanedione" on Friday August 26th at 8am at the Omni Shoreham, 2500 Calvert Street NW (at Connecticut Ave.) Washington, District of Columbia.

The Office of Environmental Health Hazard Assessment (OEHHA) has extended the public comment period soliciting information as to whether hydrogen cyanide and cyanide salts meet the authoritative bodies listing criteria set forth in the Proposition 65 regulations. The comment period scheduled to close on August 3, 2011 has now been extended until August 31, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency has added α-methyl styrene (CAS No. 98-83-9) to the list of chemicals known to the state to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing was effective July 29, 2011.

Effective July 29, 2011, the Office of Environmental Health Hazard Assessment (OEHHA) has added sulfur dioxide (CAS No. 7446-09-5) to the list of chemicals known to the State to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65).

On August 13, 2010, the Office of Environmental Health Hazard Assessment (OEHHA) issued a Notice announcing the proposed adoption of the Maximum Allowable Dose Level (MADL) for chromium (hexavalent compounds). Following the necessary approval steps, the MADL for chromium (hexavalent compounds) has been adopted and will become effective July 29, 2011.

The California Environmental Protection Agency’s Carcinogen Identification Committee (CIC) serves as the State’s qualified experts for determining whether a chemical has been clearly shown through scientifically valid testing according to generally accepted principles to cause cancer. Fluoride and its salts, and tris(1,3-dichloro-2-propyl) phosphate will be considered for possible listing by the CIC at its next meeting scheduled for Wednesday and Thursday, October 12 and 13, 2011. This notice marks the beginning of a 60-day public comment period on these two documents. OEHHA must receive comments and any supporting documentation by 5:00 p.m. on Tuesday, September 6, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding imazalil (CAS No. 35554-44-0) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of imazalil is effective May 20, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- androstenedione (CAS No. 63-05-8), dibromoacetonitrile (CAS No. 3252-43-5), hexachlorobutadiene (CAS No. 87-68-3), and malonaldehyde, sodium salt (CAS No. 24382-04-5) -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of the four chemicals is effective May 3, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding four chemicals -- cyclopenta[cd]pyrene (CAS No. 27208-37-3), ethanol in alcoholic beverages, leather dust, and salted fish, Chinese-style -- to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of these four chemicals is effective April 29, 2011.

EPA announces the release of the Toxicological Review of Methanol (Non-Cancer) in the Apr 18, 2011 Federal Register Notice. This draft assessment is provided for public viewing and comment. Public comments received on the Toxicological Review within 60 days after the release of the FRN will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in their revisions.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding epoxiconazole (CAS No. 135319-73-2) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65 ). The listing of epoxiconazole is effective April 15, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) is presenting draft documents for discussion by the Scientific Review Panel on Toxic Air Contaminants at its meeting on May 3, 2011. When finalized and adopted, these RELs will be added to the compound-specific toxicity reviews and summary tables which appear as appendices to the Technical Support Document for the Derivation of Noncancer Reference Exposure Levels.

The EPA has released 42 declassified documents revealing the identities of chemicals in health and safety studies originally submitted as confidential. This is another action in EPA’s effort to increase transparency related to TSCA and to provide greater access to chemical information.

The Committee for Risk Assessment (RAC) adopted its two first opinions at its meeting of 8-11 March on proposals submitted by France. The first was to restrict dimethylfumarate (DMFu) in articles and the second to restrict lead and its compounds in jewellery. In a parallel meeting the Committee for Socio-economic Analysis (SEAC) agreed on draft opinions for the same restriction proposals.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4,5)-decane) (CAS No. 71526-07-3), MON 13900 (furilazole) (CAS No. 121776-33-8) and pymetrozine (CAS No. 123312-89-0) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 651). The listing of the three chemicals is effective March 22, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) has added S,S,S-tributyl phosphorotrithioate (Tribufos, DEF) (CAS No. 78-48-8) to the list of chemicals known to the state to cause cancer. It has also added Acrylamide (CAS No. 79-06-1) to the list of chemicals known to the state to cause reproductive toxicity. Both of these listings are effective February 25, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) announces the availability for public review of the hazard identification document entitled: “Evidence on the Developmental and Reproductive Toxicity of Sulfur Dioxide.” This notice marks the beginning of a 60-day public comment period on this document.

The European Chemicals Agency (ECHA) has today published proposals to identify seven chemicals as Substances of Very High Concern (SVHC) and possible candidates for authorisation. In addition, an amendment to one substance already on the Candidate List is proposed. Interested parties are invited to comment on the proposals by 7 April 2011.

ECHA has called for testing information on fourteen substances. The deadline for submitting information is March 31, 2011.

OEHHA is initiating the development of hazard identification materials on these chemicals: Clomiphene and its salts; 2,6-Dimethyl-N-nitrosomorpholine; Haloperidol; Tris(1,3-dichloro-2-propyl) phosphate (TDCPP). Hazard identification materials for each of the four chemicals will be presented at future meetings of the CIC for Committee review for possible listing under Proposition 65.

On January 7, 2011, OEHHA published a notice in the California Regulatory Notice Register proposing to establish a specific regulatory level posing no significant risk for 4-methylimidazole. OEHHA has received a request from an interested party for a public hearing, consequently the public comment period on this proposed amendment has been extended to 5:00 p.m., Thursday, March 24, 2011.

The European Chemicals Agency (ECHA) has called for information on testing proposals involving vertebrate animals for nine substances. The deadline for submitting information is March 12, 2011.

ECHA would like to receive data on Aluminum Triformate and Reaction Mass of 1-(1-Methyl-2-(1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yloxy)ethoxy)-propan-2-ol and 1-(2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yloxy)propoxy)-propan-2-ol and 2-(2-(1,7,7-trimethylbicyclo-[2.2.1]hept-2-yloxy]-propoxy)-propan-1-ol and 2-(1-Methyl-2-(1,7,7-trimethylbicyclo[2.2.1]hept-2-yloxy)ethoxy)-propan-1-ol. The deadline for submitting information is March 7, 2011.

OEHHA intends to list the chemicals MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4.5)decane), MON 13900 (furilazole), and pymetrozine as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being taken under the authoritative bodies listing mechanism.

The Office of Environmental Health Hazard Assessment (OEHHA) has extended the public comment period on the proposed Public Health Goal (PHG) for Hexavalent Chromium until February 15, 2011.

The European Chemicals Agency has submitted to the European Commission a recommendation that eight chemical substances of very high concern should in future not be used without authorisation. Four of the substances are classified as both carcinogenic and toxic to reproduction, three as carcinogenic and one as toxic to reproduction. They are all used in processes or products to which workers or consumers are exposed.

ECHA would like to receive genetic toxicity data on Hexahydro-1,3,5-trimethyl-1,3,5-triazine and reproductive and sub-chronic toxicity data on Tri-C18-22 (even numbered)-alkyl 2-hydroxypropane-1,2,3-tricarboxylate. The deadline for submitting information is February 25, 2011.

The European Chemicals Agency (ECHA) has issued proposals for the harmonised classification and labelling of three substances: Ammoniumpentadecafluorootanoate (APFO), Perfluorooctanic acid (PFOA) and its salts, and p-tert-butylphenol. The deadline for comments is February 21, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding 4-methylimidazole (CAS No. 822-36-6) to the list of chemicals known to the state to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing of 4-methylimidazole is effective January 7, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency has adding Metam Potassium to the list of chemicals known to the State to cause cancer for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). Metam Potassium was listed effective December 31, 2010.

On October 22, 2010, OEHHA published a notice in the California Regulatory Notice Register soliciting information relevant to the evaluation of kresoxim-methyl (CAS No. 143390-89-0) for listing on Cal Prop 65. The initial 60 day public comment period was to have closed on December 21, 2010, but OEHHA has received a request for an extension of the comment period. OEHHA hereby extends the public comment period for this chemical to January 20, 2011.

The U.S. Environmental Protection Agency (EPA) is announcing the availability of literature searches for four IRIS assessments, acetaldehyde (CAS No. 75-07-0), hexachlorobutadiene (CAS No. 87-68-3), hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) (CAS No. 121-82-4), and naphthalene (CAS No. 91-20-3) and requesting scientific information on health effects that may result from exposure to these chemical substances.

On September 21, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Hexachloroethane (HCE): In Support of the Summary Information in the Integrated Risk Information System (IRIS). Completing this review, a final report of the comments from the workshop were collected and is now available.

On October 22, 2010, OEHHA published a notice soliciting information relevant to the evaluation of cocamide diethanolamine (coconut oil acid diethanolamine condensate) (CAS No. 68603-42-9) for listing on Cal Prop 65. The initial 60 day public comment period was to have closed on December 21, 2010, but OEHHA has received a request for an extension of the comment period. OEHHA hereby extends the public comment period for this chemical to February 1, 2011.

The European Chemicals Agency has added eight chemical substances to the Candidate List of Substances of Very High Concern (SVHC) for Authorisation. Companies are advised to check the potential obligations that result from this listing.

ECHA would like to receive reproductive and sub-chronic toxicity data on Reaction mass of disodium hydroxysulfinatoacetate and disodium hydroxysulfonatoacetate. The deadline for submitting information is January 27, 2011.

The Office of Environmental Health Hazard Assessment (OEHHA) is adding Avermectin B1(abamectin) to the list of chemicals known to the State to cause reproductive toxicity for purposes of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65). The listing is effective December 3, 2010.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) has found that imazalil meets the criteria for listing as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being taken under the authoritative bodies listing mechanism.

The Member State Committee (MSC) agreed unanimously on the identification of eight Substances of Very High Concern (SVHCs) that will be added to the Candidate List and may thus become subject to authorisation. The Committee also gave a favourable opinion on ECHA's draft recommendation for adding eight new substances to the Authorisation List.

In June of 2008, the Office of Environmental Health Hazard Assessment (OEHHA) published requests for relevant information with regard to the possible listing of three chemicals under Prop 65 as known to cause reproductive toxicity: thiabendazole (CAS No. 148-79-8), thiabendazole hypophosphate salt (CAS No. 28558-32-9) and imazalil (CAS No.35554-44-0). OEHHA has determined that there is insufficient evidence that the criteria in the regulation for these chemicals have been met.

ECHA would like to receive reproductive and sub-chronic toxicity data on Mono- and/or di- and/or tri(1-phenylethyl)-m-cresol and p-cresol. The deadline for submitting information is January 17, 2011.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether Androstenedione, Dibromoacetonitrile, Hexachlorobutadiene, and Malonaldehyde, Sodium Salt meet the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986.

ECHA would like to receive reproductive and sub-chronic toxicity data on Cyclohexane-1,4-diyldimethanol; 1,3,5-tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione; C20-C22 (even numbered, linear and branched) and C24 (branched) alkenes; 3-amino-4-octanol; and Reaction mass of (rel-2R,4R)-tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran-4-ol and (rel-2R,4S)-tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran-4-ol. The deadline for submitting information is January 3, 2011.

This second list of chemicals expands the EDSP in an effort to include all pesticides, required by FFDCA, and adds priority drinking water chemicals into the program for screening as authorized by SDWA section 1457.

The Office of Environmental Health Hazard Assessment (OEHHA) has added methyl isocyanate (MIC) (CAS No. 624-83-9) to the list of chemicals known to the State to cause reproductive toxicity. The listing is effective November 12, 2010.

On September 23, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Dichloromethane (Methylene Chloride): In Support of the Summary Information in the Integrated Risk Information System (IRIS). A final report of the comments from the workshop were collected and is now available.

The RAC has adopted opinions on four proposals for harmonised classification and labelling across Europe. The opinions concern fuberidazole, TNPP (tris(nonylphenyl)phosphite), lucirin (Diphenyl(2,4,6-trimethylbenzoyl) phosphine oxide) and acequinocyl.

OEHHA is requesting information as to whether the following chemicals meet the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986: Cocamide Diethanolamine, Kresoxim-Methyl, Mon 4660, Mon 13900, Pymetrozine, and Tetraconazole.

ECHA would like to receive reproductive and sub-chronic toxicity data on Reaction Mass of (rel-2R,4R)-tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran-4-ol and (rel-2R,4S)-tetrahydro-4-methyl-2-(2-methylpropyl)-2H-pyran-4-ol (CASRN 63500-71-0). The deadline for submitting information is December 6, 2010.

EPA is soliciting public nominations for chemical substances for its 2011 agenda for the IRIS Program. EPA invites the public to submit nominations for substances to be considered for an assessment or reassessment in its IRIS Program using the form provide on the IRIS Web site.

OEHHA has received another request from an interested party seeking an extension of the comment period due to unique extenuating circumstances concerning the submission of complete and relevant scientific information for Tribufos or DEF. OEHHA hereby extends the public comment period for Tribufos or DEF to 5 p.m., Monday, November 15, 2010.

Effective October 8th, 2010, 1,3-dichloro-2-propanol (1,3-DCP) (CAS No. 96-23-1), 3-monochloropropane-1,2-diol (3-MCPD) (CAS No. 96-24-2), and Spirodiclofen (CAS No. 148477-71-8) are listed as Known to the State of California to Cause Cancer.

Public consultation on harmonised classification and labelling for Pitch, coal tar, hight temp. and Aluminium-magnesium-zinc-carbonate-hydroxide started on 01/10/2010

EPA announces the release of the Toxicological Review of Hexavalent Chromium in the September 30, 2010, Federal Register. This draft assessment is provided for public viewing and comment.

OEHHA announces the availability for public review of the documents (updated 09/30/10) entitled: "Evidence on the Carcinogenicity of 1,3-Dichloro-2-propanol (1,3 DCP)" and "Evidence on the Carcinogenicity of 3-Monochloropropane-1,2-diol (3-MCPD)."

EPA announces the release of the Toxicological Review of Urea (External Review Draft) in the September 28, 2010 Federal Register Notice. This draft assessment is provided for public viewing and comment.

OEHHA has received a request from an interested party seeking an extension of the comment period to allow for the submission of complete and relevant scientific information. OEHHA hereby extends the public comment period for Tribufos to 5 p.m., Wednesday, October 13, 2010.

The RAC agreed with the proposal from Ireland to harmonise the classification of TDCP (Tris[2-chloro-1-(chloromethyl)ethyl] phosphate) across Europe as a carcinogen. This substance has currently no harmonised classification at EU level.

On September 21 22, 2010, the Carcinogen Identification Committee of OEHHA’s Science Advisory Board will meet to consider whether 1,3-Dichloro-2-propanol (1,3-DCP) and 3-Monochloropropane-1,2-diol (3-MCPD) should be added to the list of chemicals known to the state to cause cancer or reproductive toxicity.

ECHA would like to receive reproductive and sub-chronic toxicity data on 1,5-bis[1,2-bis(ethoxycarbonyl)ethylamino]-2-methylpentane.

ECHA would like to receive reproductive and sub-chronic toxicity data on 1,6-Bis((dibenzylthiocarbamoyl)disulfanyl)hexane and (1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate.

The European Chemicals Agency (ECHA) has today published proposals to identify eleven chemicals as Substances of Very High Concern (SVHC) and possible candidates for authorisation.

CERHR invites the submission of information about ongoing studies or upcoming publications on the health effects of low-level lead exposure. This information will be considered in the CERHR’s evaluation of the potential health effects of exposure to low-level lead.

EPA to take action on benzidine dyes, hexabromocyclododecane (HBCD) and nonylphenol (NP)/nonylphenol ethoxylates (NPEs). The plans identify a range of actions the agency is considering under the Toxic Substances Control Act (TSCA).

OSHA is hosting a Web forum asking for stakeholder input in identifying chemicals most in need of oversight to protect workers. The Forum will allow stakeholders to identify harmful chemicals and explain why OSHA should focus on these chemicals in developing long- and short-term solutions for reducing workers' exposure.

EPA is announcing a 45-day public comment period for the draft document, Nanomaterial Case Study: Nanoscale Silver in Disinfectant Spray (External Review Draft), as announced in the August 13, 2010 Federal Register Notice. The deadline for comments is September 27, 2010

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) has proposed a MADL of 8.2 μg/day (oral) for chromium (hexavalent compounds).

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list S,S,S-tributyl phosphorotrithioate as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being taken under the authoritative bodies listing mechanism.

EPA announces an external peer review meeting for the review of the draft report, Toxicological Review of Hexachloroethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) to be hosted on September 21, 2010 in Arlington, VA.

OEHHA is proposing to add the qualifying term, “(oral)” to the level to clarify that the adopted MADL of 4.1 micrograms per day for cadmium was and continues to be specific for the oral route of exposure.

These chemicals will be discussed at the next meeting of the Proposition 65 Carcinogen Identification Committee (CIC) scheduled for Tuesday and Wednesday, September 21 and 22, 2010.

On June 21-22, 2010 NTP scientists presented draft substance reports for the final three compounds being considered for possible listing in the report for the Board of Scientific Counselors' consideration and public comment.

ECHA launches today a public consultation on its draft recommendation of eight substances to be included in the Authorisation List . These substances are: Diisobutyl phthalate (DIBP); Diarsenic trioxide; Diarsenic pentaoxide; Lead chromate; Lead sulfochromate yellow (C.I. Pigment Yellow 34); Lead chromate molybdate sulfate red (C.I. Pigment Red 104); Tris (2-chloroethyl) phosphate (TCEP); 2,4-Dinitrotoluene. Interested parties can submit comments until 30 September 2010.

Documents entitled: "Evidence on the Carcinogenicity of 1,3-Dichloro-2-propanol (1,3 DCP)" and "Evidence on the Carcinogenicity of 3-Monochloropropane-1,2-diol (3-MCPD)" are now available. These two substances are being considered for possible listing under Proposition 65 by the CIC at its next meeting scheduled for Tuesday and Wednesday, September 21 and 22, 2010.

OEHHA has received a request from an interested party seeking an extension of the comment period to allow more time for the preparation of comments on the proposed MDI and TDI RELs. OEHHA has extended the public comment period for to 5 p.m., Thursday, July 22, 2010.

OEHHA is unable to complete the rulemaking process within the time allowed under the Administrative Procedure Act and is withdrawing its proposal to establish a specific level posing no significant risk using expedited methodology for Fumonisin B1.

The following substances may become subject to authorisation: Trichloroethylene ; Boric acid ; Disodium tetraborate anhydrous ; Tetraboron disodium heptaoxide hydrate ; Sodium chromate ; Potassium chromate ; Ammonium dichromate ; Potassium dichromate.

Cal/EPA has changed the basis for listing Chlorsulfuron from "developmental, female, male" to only "developmental, female" based on new information from the U.S. EPA.

The Office of Environmental Health Hazard Assessment (OEHHA) is soliciting public comments on a draft document describing proposed revised Reference Exposure Levels (RELs) for nickel and nickel compounds.

This draft IRIS health assessment addresses both noncancer and cancer human health effects that may result from chronic inhalation exposure to this chemical.

ECHA would like to receive sub-chronic toxicity (90-day), reproductive toxicity (developmental toxicity), and reproductive toxicity (two-generation reproductive toxicity) for 2,3-epoxypropyl neodecanoate (CAS 26761-45-5) by July 12, 2010 in order to avoid duplicate animal testing.

The Office of Environmental Health Hazard Assessment (OEHHA) is releasing draft document describing proposed Reference Exposure Levels (RELs) for caprolactam to solicit public comment.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding N,N-Dimethylacetamide (CAS No. 127-19-5) to the list of chemicals known to the state to cause reproductive toxicity.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether S,S,S-tributyl phosphorotrithioate meets the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986.

This final report provides a comprehensive assessment of the exposure of Americans to this class of persistent organic pollutants.

EPA is conducting a peer review of the scientific basis supporting the human health hazard and dose-response assessment of hexachloroethane that will appear on the Integrated Risk Information System (IRIS) database.

The information on 2,4-dinitrotoluene and lead chromate is needed to help ECHA to judge whether they should be recommended as substances which should be subject to authorisation.

ECHA is seeking information on C8-C26 branched and linear hydrocarbons - Distillates to avoid unnecessary animal testing.

The EP A is also requesting scientific information on health effects that may result from exposure to these chemical substances: Diisobutyl Phthalate (DIBP), Diisononyl Phthalate (DINP), Dipentyl Phthalate (DPP), and Polychlorinated Biphenyls.

In a Federal Register notice published April 23, the CSB announced it is seeking public comment on the design of a Congressionally mandated study on the use of methyl isocyanate (MIC) in the manufacturing of certain pesticides, and the feasibility of implementing safer alternatives to protect workers and the public from a potential release.

OEHHA has released draft documents describing proposed revised Reference Exposure Levels (RELs) for toluene diisocyanate and methylene diphenyl diisocyanate in order to solicit public comment.

OEHHA proposes to establish a specific regulatory level having a maximum allowable dose (MADL) for Di-isodecyl Phthalate (DIDP).

Preliminary Agenda includes the peer review of 12th Report on Carcinogens (RoC) draft substance profiles and discussions of proposed CERHR research concepts and NTP Testing Program Nominations.

EPA issued an Advance Notice of Proposed Rulemaking (ANPR) on the Agency's potential reassessment of its current authorizations for PCB use and distribution in commerce. The Agency will hold a series of public meetings around the country to provide stakeholders with the opportunity to provide comments, data and information on certain areas of the PCB regulations under the Toxic Substances Control Act (TSCA).

The Agency announced that it is proposing to add 16 chemicals to the TRI list of reportable chemicals. The proposed chemicals are ones that have been classified as “reasonably anticipated to be a human carcinogen” by the National Toxicology Program (NTP) in their Report on Carcinogens (RoC).

Bromochloroacetic acid (CAS No. 5589-96-8), Cumene (CAS No. 98-82-8) and Diclofop-methyl (CAS No. 51338-27-3) Listed as known to the state to cause Cancer.

This ISA is intended to update and revise the scientific assessment presented in the Air Quality Criteria for Lead published in October, 2006.

The European Chemicals Agency has added Acrylamide (EC No 201-173-7 and CAS No 79-06-1)1 to the Candidate List of Substances Very High Concern (SVHC) for Authorisation.

The listings are effective March 30, 2010.

OEHHA has scheduled a public forum on April 20th, 2010 and has extended the written public comment period to May 13, 2010.

On January 26, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Ethyl Tertiary Butyl Ether (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available on the EPA website.

The preliminary agenda topics are the agency's recent activities on Soy Infant Formula and low-level Lead.

The OEHHA announces a 60-day extension of the public comment period on the draft technical support document for the proposed Public Health Goal (PHG) for styrene in drinking water.

On February 5, 2010, OEHHA published a notice soliciting information relevant to the evaluation of epoxiconazole. OEHHA subsequently received a request from an interested party seeking an extension of the comment period and has consequently extended the public comment period until April 7, 2010.

The proposed regulation would adopt a MADL of 140 micrograms per day, which is 700 times greated than the current NSRL of 0.2 micrograms per day.

This action is being taken under the authoritative bodies listing mechanism. Acrylamide meets the criteria for listing as known to the State to cause reproductive toxicity under Proposition 65, based on findings of NIOSH and NTP-CERHR.

OEHHA has determined that Metam potassium meets the regulatory criteria for listing as known to the State to cause cancer based on the findings of the U.S. EPA (U.S. EPA, 1995; 2005; 2007; 2009).

The public consultation on harmonised classification and labelling for acequinocyl, metazachlor, tris(nonylphenyl) phosphate and bifenthrin begins on 2/22/2010.

This draft assessment is provided for a 60-day public viewing and comment period.

The “No Significant Risk Level” (NSRL) is defined in regulation as the daily intake level posing a 10-5 lifetime risk of cancer. The NSRLs for p-chloroaniline hydrochloride and p-chloroaniline are calculated to be 1.9 μg/day and 1.5 μg/day, respectively.

The NRC report concludes that the EPA's classification of tetrachloroethylene as "likely to be a human carcinogen" is appropriately supported.

OEHHA is requesting public comment concerning whether this chemical meets the criteria for listing as known to the State to cause reproductive toxicity under Proposition 65.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals diclofop-methyl and epoxiconazole as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals bromochloroacetic acid and cumene as known to the State to cause cancer under the Safe Drinking Water and Toxic Enforcement Act of 1986.

Carbaryl (CAS No.63-25-2) is being listed as a chemical known to the State of California to cause cancer. The listing of this chemical is based on formal identification by an authoritative body (the U.S. Environmental Protection Agency (U.S. EPA)), that the chemical causes cancer.

On January 6, 2010, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Chloroprene (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

EPA announces the details of an external peer review meeting to be held on March 3-4, 2010. This draft document, Exposure Factors Handbook 2009 Update (External Review Draft) was previously provided for public viewing and comment.

List of 66 chemicals is part of the pilot rule-making process related to the previously enacted Children’s Product Safety Act.

The California Environmental Protection Agency's Office of Environmental Health Hazard Assessment (OEHHA) intends to list the chemicals 1-dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE) and nitrobenzene as known to the State to cause reproductive toxicity under the Safe Drinking Water and Toxic Enforcement Act of 1986.

EPA is announcing the Integrated Science Assessment (ISA) for Carbon Monoxide (CO) Final Report. This is EPA’s latest evaluation of the scientific literature on the potential human health and welfare effects associated with ambient exposures to CO. The development of this document is part of the Agency's periodic review of the national ambient air quality standards (NAAQS) and will provide the scientific basis to inform EPA decisions related to the review of the current CO standards.

On December 17, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Cis-and Trans-1,2-Dichloroethylene (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

On December 14, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Hydrogen Cyanide and Cyanide Salts (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

On December 10, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Trichloroacetic Acid (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

ECHA seeking comment on White Spirits, Fuberidazole, and Thiacloprid.

FDA has released a 2010 update on the status of its activities to answer key questions and clarify uncertainties about the risks of BPA.

A listening session will be held on February 23, 2010, during the public comment period for this draft document.

CERHR invites written public comments by March 1, 2010.

The World Health Organization's department of Food Safety and Zoonoses has released a call for data and call for experts to consult on their planned assessment of the toxicological and health effects of bisphenol A.

The European Chemicals Agency has added 14 chemical substances to the Candidate List of Substances of Very High Concern (SVHC) for authorisation. Companies manufacturing or importing these substances need to check their potential obligations that result from the listing.

OEHHA has received a request from an interested party seeking an extension of the comment period to allow for the submission of complete and relevant scientific information for spirodiclofen. OEHHA hereby extends the public comment period two weeks to 5 p.m., Monday, January 25, 2010.

In view of this change in the cancer classifications of the chemicals by the U.S. EPA, OEHHA will not proceed with the proposed listing of these chemicals as known to cause cancer via the authoritative bodies mechanism at this time.

EPA announces the details of an external peer-review workshop to be held on January 26, 2006. This draft assessment, Toxicological Review of Ethyl Tertiary Butyl Ether: In Support of Summary Information on the Integrated Risk Information System (IRIS) was previously provided for public viewing and comment.

EPA is announcing a listening session to be held on January 26, 2006, during the public comment period for the draft document entitled, Toxicological Review of Trichloroethylene: In Support of Summary Information on the Integrated Risk Information System (IRIS).

Results of the November 19, 2009 Meeting now available on the NTP website.

The NTP invites public comment on the recommendation from an expert panel on the listing status for formaldehyde in the 12th RoC and the scientific justification for the recommendation.

Wood dust and zidovudine (AZT) are being added to the list as known to the state to cause cancer. Tert-Amyl methyl ether (TAME) and ethyl-tert-butyl ether (EBTE) are being added as known to the state to cause reproductive toxicity. These listings are effective December 18, 2009.

EPA will will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of 1,1,2,2-Tetrachloroethane: In Support of Summary Information in the Integrated Risk Information System (IRIS)"

The Fourth National Report on Human Exposure to Environmental Chemicals is the most comprehensive assessment to date of the exposure of the U.S. population to chemicals in our environment.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is adding molinate (CAS No. 2212-67-1) to the list of chemicals known to the state to cause reproductive toxicity for purposes of Proposition 65. The listing of molinate is effective December 11, 2009.

OEHHA has received requests to extend the comment period for (1,3-DCP), 3’monochloropropane-1,2-diol (3-MCPD), and perfluorooctanoic acid (PFOA) and its salts and transformation and degradation precursors to allow for the submittal of complete and relevant scientific information.

ECHA´s Member State Committee identified today 15 new chemical substances for the Candidate List of substances of very high concern. The List will formally be updated in January 2010.

On November 4, a 10-member independent scientific expert panel convened by the National Toxicology Program (NTP) voted unanimously to list formaldehyde as a "known human carcinogen" in the upcoming 12th NTP Report on Carcinogens (RoC).

The European Chemicals Agency (ECHA) is calling for information on the long-term health effects of “4-((Triethoxysilyl)methyl)morpholine”. This is a public consultation foreseen by the REACH Regulation for testing proposals involving animals.

EPA will will convene an independent panel of experts and organize and conduct an external peer-review workshop to review the external review draft document titled, "Toxicological Review of Chloroprene: In Support of Summary Information in the Integrated Risk Information System (IRIS)"

OEHHA has determined that Carbaryl and Spirodiclofen meet the regulatory criteria for listing based on the findings of the U.S. EPA.

The European Chemicals Agency (ECHA) is calling for information on the health effects of a new substance with the name of “Polysulfo{5-hydroxy-1-naphthalen-2-yl-[4-[4-(2-sulfatoethyl-sulfonyl)-phenyl]diazenyl]-1H-pyrazole-3-carboxylic acid}, alkali metal salt”. This is a public consultation foreseen by the REACH Regulation for testing proposals involving animals.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether three chemicals meet the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism.

The Council decided not to oppose a Commission decision to establish a further list of indicative occupational exposure limit values (IOELVs) for the protection of workers from chemical risks.

This draft assessment is provided for public review and comment. Public comments received on the Toxicological Review within 90 days after the release of the FRN (on or before February 1, 2010) will be provided to the external peer reviewers for their consideration.

The California Environmental Protection Agency’s Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) and nitrobenzene meet the criteria for listing as reproductive toxicants under the Safe Drinking Water and Toxic Enforcement Act of 1986.

The U.S. Environmental Protection Agency has issued the first test orders for pesticide chemicals to be screened for their potential effects on the endocrine system. Endocrine disruptors are chemicals that interact with and disrupt the hormones produced or secreted by human and animal endocrine systems, which regulate growth, metabolism and reproduction.

This notice announces the final priority data needs for six priority hazardous substances as part of the continuing development and implementation of the ATSDR Substance Specific Applied Research Program (SSARP). This notice also serves as a continuous call for voluntary research proposals.

The preliminary agenda, roster of BSC members and ad hoc reviewers, background materials for agenda topics, public comments, and any additional information, when available, will be posted on the BSC meeting Web site.

On April 25, 2008, the Toxicological Review of ethylene glycol monobutyl ether (EGBE) was released for external review. Comments from the first and second rounds of this review were consolidated and reports are now available.

On August 4, 2009, an external peer review panel workshop was hosted by an independent contractor on the Toxicological Review of Pentachlorophenol (External Review Draft). Completing this review, a final report of the comments from the workshop were collected and is now available.

The intent of the IRIS Update Project is to revisit all dose-response assessment toxicity values such as oral reference doses (RfDs), inhalation reference concentrations (RfCs), cancer oral slope factors, and cancer inhalation unit risks in IRIS with a posting or entry date of more than 10 years old.

OEHHA's response to the DuPont request is pending.

The Center for the Evaluation of Risks to Human Reproduction (CERHR) invites public comments on the draft expert panel report which is an update to a previous expert panel evaluation completed in 2006. The expert panel will meet in December to review and revise the draft expert panel report and reach conclusions regarding whether exposure to soy formula is a hazard to human development.

The SIN List 1.0 has been updated with 89 new substances. This update of the SIN List is due to an extension of the list of substances classified within the European Union as CMRs– Carcinogenic, Mutagenic, and toxic to Reproduction. Based as always on the REACH criteria for Substances of Very High Concern, the SIN List now contains 356 substances to be Substituted Now!

The Office of Environmental Health Hazard Assessment (OEHHA) is requesting information as to whether bromochloroacetic acid and cumene meet the criteria for listing under the Safe Drinking Water and Toxic Enforcement Act of 1986. This action is being proposed under the authoritative bodies listing mechanism.

The Office of Environmental Health Hazard Assessment (OEHHA) has initially selected five chemicals for the CIC’s review for possible listing under Proposition 65 and is initiating the development of hazard identification materials for these chemicals. Under consideration are: 3-Monochloropropane-1,2-diol; 1,3-Dichloro-2-propanol; Fluoride and its salts; Diisononyl phthalate (DINP); Perfluorooctanoic acid (PFOA) and its salts and transformation and degradation precursors.

The CCL 3 is a list of contaminants that are currently not subject to any proposed or promulgated national primary drinking water regulations, that are known or anticipated to occur in public water systems, and which may require regulation under SDWA.

This amendment to Section 25705(d) would adopt 1.5 micrograms/day as the No Significant Risk Level (NSRL).

The list is based on the complete registration dossiers submitted by companies to ECHA before 24 September 2009 and contains 156 substances.

The U.S. Environmental Protection Agency is launching this year a comprehensive new evaluation of the pesticide atrazine to determine its effects on humans. At the end of this process, the agency will decide whether to revise its current risk assessment of the pesticide and whether new restrictions are necessary to better protect public health.

EPA is announcing a public comment period for the external review draft document titled, ``Toxicological Review of Chloroprene: In Support of Summary Information on the Integrated Risk Information System (IRIS)''.

Comments received during the interagency science discussion on 2-hexanone will be posted with the external review draft within the next few weeks.

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of Trichloroacetic Acid: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on November 4, 2009. Comments received during the interagency science discussion on Trichloroacetic Acid will be posted with the external review draft within the next few weeks.

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of Cis-and Trans-1,2-Dichloroethylene: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on October 19, 2009. Comments received during the interagency science discussion on Cis- and Trans-1,2-Dichloroethylene will be posted with the external review draft within the next few weeks.

EPA is announcing a public comment period to review the draft document titled, "Toxicological Review of 1,1,2,2-Tetrachloroethane: In Support of Summary Information on the Integrated Risk Information System (IRIS) (External Review Draft)." EPA is also announcing a public listening session to be held on October 14, 2009.

EPA is announcing a listening session to be held on October 7, 2009, for the external review draft document entitled, "Toxicological Review of Ethyl Tertiary Butyl Ether: In Support of Summary Information on the Integrated Risk Information System (IRIS)."

This draft ISA document represents a concise synthesis and evaluation of the most policy-relevant science and will ultimately provide the scientific bases for EPA's decision regarding whether the current standards for CO sufficiently protect public health and the environment.

EPA's IRIS Program is announcing a public comment period to review the draft document titled, "Toxicological Review of Hydrogen Cyanide and Cyanide Salts (External Review Draft)." EPA is also announcing a public listening session to be held on October 27, 2009.

Comments received during the interagency science discussion on chlordecone will be posted with the external review draft within the next few weeks

On September 16, 2009 an Order amending the Domestic Substances List (DSL) to apply the Significant New Activity (SNAc) provisions specified under subsection 81(3) of CEPA 1999 for Disperse Orange 5 (CAS No. 6232-56-0), substance in Batch 5 of the Challenge, was published in the Canada Gazette, Part II.

The Office of Environmental Health Hazard Assessment (OEHHA) within the California Environmental Protection Agency is hereby announcing a 30-day extension of the public comment period on the draft technical support document for the proposed Public Health Goal (PHG) for antimony in drinking water.

ECHA publishes public consultation on the proposal to harmonize the classification and labelling of three chemical substances. Comments are welcome on the proposal within the next 45 days.

The European Chemicals Agency (ECHA) has published proposals to identify chemicals as Substances of Very High Concern (SVHC). Interested parties are welcome to comment on these 15 substances within the next 45 days.

The NTP invites the submission of public comments on the draft background document for formaldehyde. The expert panel will meet on November 2–4, 2009 to peer review the draft background document for formaldehyde and, once completed, make a recommendation regarding the listing status in the 12th Edition of the RoC (12th RoC).

This document establishes a PHG for 1,2,3-trichloropropane of 0.0007 parts per billion, versus the current Notification Level of 0.005 ppb, set in 2005. The PHG is based on an updated cancer potency calculation.

On August 19th, 2009, an Order amending DSL to apply the Significant New Activity (SNAc) provisions specified under subsection 81(3) of CEPA 1999 to 6 substances was published in the Canada Gazette, Part II.

The draft Toxicological Review of Ethyl Tertiary Butyl Ether provides scientific support and rationale for the hazard and dose-response assessment pertaining to chronic exposure to ethyl tertiary butyl ether. Public comments received within 60 days will be provided to the external peer reviewers for their consideration.

On August 19th, 2009, an Order amending the Domestic Substances List (DSL) to apply Significant New Activity (SNAc) provisions specified under subsection 81(3) of CEPA 1999 to Fluorotriphenyltin and tetraphenyltin, was published in the Canada Gazette, Part II.

On August 19, 2009 an Order amending the Domestic Substances List (DSL) to apply the Significant New Activity (SNAc) provisions specified under subsection 81(3) of CEPA 1999 to five of the substances in Batch 4 (CAS No. 1154-59-2, 1176-74-5, 64325-78-6, 68443-10-7 and 70776-86-2), was published in the Canada Gazette, Part II.

EPA releases an updated policy and procedure guidance for conducting IRIS Peer Reviews which discusses the issue of conflict of interest and and appearance of bias or lack of impartiality when a peer review panel is being formed.